This half-hour comedy focuses on the bizarre experiences of fresh-faced medical intern John "J.D." Dorian (Zach Braff) as he embarks on his healing career in a surreal hospital crammed full of unpredictable staffers and patients – where humor and tragedy can merge paths at any time.

Joining the rumpled J.D. in his exhilarating brave new world are his college buddy, Chris Turk (Donald Faison, "Clueless"), an intern with a more elite surgical group, and J.D.'s fellow medical intern, the beautiful and driven Elliot Reid (Sarah Chalke, "Roseanne"). Keeping the new interns on their toes are: the fatherly chief of medicine, Dr. Bob Kelso (Ken Jenkins); the abrasive, worldly Dr. Perry Cox (John McGinley), and the caring but slightly jaded nurse Carla Espinosa (Judy Reyes). The hospital janitor (Neil Flynn) also never seems to miss an opportunity to harass his target.